Eye Wellness

Meibomian Gland Dysfunction

Meibomian Gland Dysfunction (MGD) is more common than we know. Many young adults are plagued with dry eyes due to MGD.

What is Meibomian Gland Dysfunction?

Meibomian glands take the name of the German doctor who studied them. These glands produce a type of oil known as meibum and are also responsible for secreting just the right amount of oil into our tears. The mixture of meibum, water, and mucus combined give us the three layers of tear film present on the ocular surface, the very liquid that keeps our eyes comfortably moist. Meibum (the oil) helps prevent the water content on the eye from evaporating, and thus drying out more quickly than tears can be produced.

Clinical diagram detailing meibomian gland dysfunction and blocked oil glands along the upper and lower eyelid margins.

Meibomian Gland Dysfunction is often the result of a combination of factors gone wrong in the oil or glands involved. Changes in the quantity or quality of oil produced, or perhaps even changes or abnormalities affecting the meibomian glands themselves, may result in a case of Meibomian Gland Dysfunction. The most commonly observed, obstructive MGD, takes place when the openings of the meibomian glands get blocked, resulting in reduced amounts of oil that reach the surface of the eye.

Hyperactive Meibomian glands can lead to lid infections, or recurrent chalazion and marginal keratitis (inflammation of the cornea) or a combination of the aforementioned conditions.

Treatment of Meibomian Gland Dysfunction is often decided only after a close examination from your eye specialist, while taking into account underlying physical conditions and the severity of the symptoms displayed by the dysfunction.

Certain physical conditions may also increase the risk of MGD developing in a person. We list a few of the common examples below:

  • High cholesterol
  • Eye diseases, such as allergic conjunctivitis
  • Damages sustained on the eyelid or cornea
  • Bacterial infections
  • Autoimmune diseases, such as rosacea, lupus or rheumatoid arthritis

Certain types of medication may hinder oil production and run the risk of MGD developing, such as:

  • Estrogen replacement therapy
  • Drugs that lower androgen levels
  • Retinoids, found in acne medication and certain types of anti-ageing creams
Close-up photograph demonstrating professional eyelid hygiene or specialized ocular surface care at our Singapore clinic.
Patient undergoing comprehensive glaucoma screening or eye pressure monitoring at our specialized center in Singapore.

Causes of Meibomian Gland Dysfunction

  • Age – The function and number of meibomian glands naturally decline with age, leading to a higher risk of dysfunction over time.
  • Ethnicity – Studies show that Asians are three times more likely to develop meibomian gland dysfunction (MGD) compared to individuals of European descent.
  • Contact Lens Use – Regular contact lens wear has been linked to an increased risk of meibomian gland dysfunction, potentially affecting tear film stability and eye lubrication.
Close-up image of safe contact lens handling or clinical verification of corneal health variables.

Symptoms of Meibomian Gland Dysfunction

Early-stage MGD is often asymptomatic, meaning most individuals may not notice any issues.

As the condition progresses and oil production decreases—either in quantity or quality—symptoms begin to appear, including burning, itching, irritation in the eyes, a persistent dry or gritty sensation (similar to having sand in the eyes), redness, soreness, or irritation of the eyelids.

A distinctive sign of MGD is an uneven or rough appearance on the inner rim of the eyelid, though not all cases exhibit this symptom.

Another symptom commonly expressed is that some people experience blurred vision that gets better when they blink.

The symptoms experienced can worsen when you engage in an activity that requires a great amount of visual attention, such as using the computer or if the air environment is dry – in Singapore, this often happens when you spend extended periods of time in an air-conditioned environment.

Complications of Meibomian Gland Dysfunction

MGD is the leading cause of dry eye syndrome (or dry eye disease). MGD may also result in inflammation of the eyelids, otherwise known as blepharitis.

Amongst these three conditions, there are many overlapping and connected causes. It is possible to have all 3 of them at once. It is currently not clearly understood which could be an underlying cause, but it is postulated that MGD causes inflammation that can lead to a development of dry eye symptoms, or that inflammation resulting from dry eye symptoms could damage the nearby meibomian glands.

Left untreated, MGD may lead to cornea disease in its advanced stages. Consult your doctor if you experience the above-described symptoms. It is far easier to treat MGD and its associated complications in their early stages and runs a much higher possibility for no lasting damage sustained to your eyes and surrounding structures.

Close-up photograph demonstrating professional eyelid hygiene or specialized ocular surface care at our Singapore clinic.
Close-up photograph demonstrating professional eyelid hygiene or specialized ocular surface care at our Singapore clinic.

Diagnosis of Meibomian Gland Dysfunction

Your eye specialist is the best source of diagnosis for meibomian gland dysfunction. Close inspection of your eyelids and the gland openings will give clues as to the general health of your oil glands. Sometimes, your eye specialist may even squeeze on your eyelids to force the oils within out.

A test known as “Schirmer’s Test” checks if your body produces enough tears. Other tests can ascertain the quality of meibum produced and the speed at which your tears evaporate.

The study of a combination of these results can give clues to whether you are indeed suffering from a case of meibomian gland dysfunction.

Medical Treatment for Meibomian Gland Dysfunction

Early stages of MGD may require no treatment as symptoms may not obstruct vision or interfere with daily living. Simple steps can be taken to manage the symptoms from home and the likelihood of recovery is substantial without medical attention.

However, if the condition worsens, medical treatment administered from medical professionals will be required. In such cases, a combination of the below courses of treatment may be prescribed to alleviate symptoms and bring the condition under control:

  • Eye lubricants
  • Antibiotics, if infection is present
  • Drugs to suppress your immune system
  • Inflammation reduction medication, such as steroids, may be administered

These could come in the form of eye drops, creams and orally ingested pills.

Close-up photograph demonstrating professional eyelid hygiene or specialized ocular surface care at our Singapore clinic.

Your eye specialist may employ the use of devices that deliver heat or pulsed light to force open clogged meibomian glands and improve symptoms. At Asia Retina, we use a combination of treatments including IPL (Intense Pulsed Light) to treat meibomian gland dysfunction effectively.

Your eye specialist will also advise you on how to care for your eyes at home. It takes a concerted effort on the patient’s end to keep up the home care procedures to reverse MGD symptoms. Remember to keep to your scheduled visits for follow up appointments for your eye specialist to track your progress, even if you feel a general alleviation of symptoms. This allows your eye specialist to keep track and detect any abnormalities early.

Schedule your consultation at our eye specialist clinic in Paragon

For urgent enquiries and appointment requests, please call or WhatsApp us directly.